… Impact of the co-morbidity of hyperuricaemia with high xanthine oxidoreductase (XOR)
activity on clinical outcomes in heart failure with preserved ejection fraction. (A) Kaplan–Meier …

… In heart failure, XOR activity is upregulated as a consequence of its increased expression
induced by inflammatory cytokines, as well as of the augmented substrate supply, due to …

… Xanthine oxidoreductase is expressed primarily in the liver and intestine, as well as in other
… XOR activity is enhanced by various stimuli, including inflammatory cytokines (ie interferon-γ…

… improved by the addition of plasma xanthine oxidoreductase (XOR) activity to the basic
predictors of age, New York Heart … significantly improved by the addition of plasma XOR activity to …

… to xanthine oxidase, a form that produces cytotoxic reactive oxygen species (ROS) [7,8].
Experimental studies using animal heart failure … We examined whether increased expression of …

… Reduced exercise capacity is an independent predictor of poor prognosis in patients with
heart failure (HF). Exercise intolerance is partly attributed to skeletal muscle abnormalities, …

… A highly sensitive assay of human plasma xanthine oxidoreductase activity using stable …
Increased plasma xanthine oxidoreductase activity deteriorates coronary artery spasm. Heart …

… cardiovascular events, heart failure, and renal dysfunction (2, 20, 58). In animal models,
inhibition of XOR activity by allopurinol, febuxostat, or topiroxostat improved cardiovascular and …

… XOR activity leads to adverse outcomes. However, high-XOR activity was not associated with
increased HF … The time-dependent changes of the high-XOR activity after admission have a …

… the cardiac tissue UA level might increase in the failing heart … that cardiac tissue XDH activity
was significantly increased in … significantly reduced cardiac XDH activity (Supplementary Fig…